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While low-intensity mechanical loading reduced HO of the tendon through downregulating the mTORC1 signaling pathway, high-intensity mechanical loading activated the mTORC1 pathway and accelerated HO in the rat Achilles tenotomy model and tendon cells in vitro [51]

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Effect of melatonin plus zinc supplementation on fatigue perception in myalgic encephalomyelitis/chronic fatigue syndrome: a randomized, double-blind, placebo-controlled trial